Genetic and functional characterization of the "male" mutation in rainbow trout
In contrast with the situation observed in mammals and birds, in which a major system of sex determination has been maintained for at least 100 million years, there is a wide variety of mechanisms controlling sex in fish. In particular, salmonids are considered to have a strictly genetic sex determination system with male heterogametry (males XY and females XX). However, unexpectedly, males have been observed in genetically homozygous female (XX) lines obtained after gynogenesis in rainbow trout Oncorhynchus mykiss. Genetic analyses of this masculinized phenotype (Mal) suggest that it is due to a recessive mutation in a minor locus of sex determination called mal.
Determining a genetic and functional characterization of the "male" mutation in rainbow trout.
The SEXYTROUT project combines genetic, genomic and transcriptomic approaches to identify this mal locus at the molecular level and the gonadal phenotypes associated with this mutation.
